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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC25C
All Species:
18.79
Human Site:
T40
Identified Species:
45.93
UniProt:
P30307
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30307
NP_001781.2
473
53365
T40
L
E
R
D
T
S
F
T
V
C
P
D
V
P
R
Chimpanzee
Pan troglodytes
XP_001171027
473
53463
T40
L
E
R
D
T
S
F
T
V
C
P
D
V
P
R
Rhesus Macaque
Macaca mulatta
XP_001112750
472
53169
T40
L
E
R
D
T
S
F
T
V
C
P
D
V
P
S
Dog
Lupus familis
XP_853059
508
57301
T40
L
E
R
E
T
S
F
T
T
C
P
D
L
P
R
Cat
Felis silvestris
Mouse
Mus musculus
P48967
447
50028
T40
L
E
R
N
T
S
F
T
I
R
S
D
F
P
E
Rat
Rattus norvegicus
P48966
574
64268
P116
L
C
M
D
S
P
S
P
M
D
P
Q
T
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507389
566
64832
Q105
V
C
L
D
S
P
S
Q
L
D
P
Q
A
Q
E
Chicken
Gallus gallus
Frog
Xenopus laevis
P30309
550
62164
T40
R
E
K
D
C
S
V
T
F
S
P
E
Q
P
L
Zebra Danio
Brachydanio rerio
NP_001108567
563
63619
K79
G
G
Q
C
E
T
P
K
R
K
K
N
L
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20483
479
54076
L41
S
R
R
A
R
R
S
L
E
L
M
S
M
D
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
95.7
74.6
N.A.
60.4
32.5
N.A.
31.7
N.A.
43.2
33.2
N.A.
26.2
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
97
81.6
N.A.
73.1
48.6
N.A.
49.4
N.A.
58.1
52.9
N.A.
44
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
60
20
N.A.
13.3
N.A.
40
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
73.3
33.3
N.A.
33.3
N.A.
53.3
33.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
0
0
0
0
10
10
0
% A
% Cys:
0
20
0
10
10
0
0
0
0
40
0
0
0
0
0
% C
% Asp:
0
0
0
60
0
0
0
0
0
20
0
50
0
10
0
% D
% Glu:
0
60
0
10
10
0
0
0
10
0
0
10
0
0
30
% E
% Phe:
0
0
0
0
0
0
50
0
10
0
0
0
10
0
0
% F
% Gly:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
10
0
10
10
0
0
0
0
% K
% Leu:
60
0
10
0
0
0
0
10
10
10
0
0
20
0
20
% L
% Met:
0
0
10
0
0
0
0
0
10
0
10
0
10
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
0
20
10
10
0
0
70
0
0
70
0
% P
% Gln:
0
0
10
0
0
0
0
10
0
0
0
20
10
10
10
% Q
% Arg:
10
10
60
0
10
10
0
0
10
10
0
0
0
0
30
% R
% Ser:
10
0
0
0
20
60
30
0
0
10
10
10
0
0
10
% S
% Thr:
0
0
0
0
50
10
0
60
10
0
0
0
10
0
0
% T
% Val:
10
0
0
0
0
0
10
0
30
0
0
0
30
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _